In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery

In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery

Blog Article

Abstract To carry out the preclinical and histological evaluation of a novel nanotechnology-based microshunt for drainage midnight drive nail polish glaucoma surgery.Twelve New Zealand White rabbits were implanted with a novel microshunt and followed up for 6 weeks.The new material composite consists of the silicone polydimethylsiloxane (PDMS) and tetrapodal Zinc Oxide (ZnO-T) nano-/microparticles.

The microshunts were inserted ab externo to connect the subconjunctival space with the anterior chamber.Animals were euthanized after 2 and 6 weeks for histological evaluation.Ocular health and implant position were assessed at postoperative days 1, 3, 7 and twice a week thereafter by slit lamp biomicroscopy.

Intraocular pressure (IOP) was measured using rebound tonometry.A good tolerability was observed in both short- fr5945 and medium-term follow-up.Intraocular pressure was reduced following surgery but increased to preoperative levels after 2 weeks.

No clinical or histological signs of inflammatory or toxic reactions were seen; the fibrotic encapsulation was barely noticeable after two weeks and very mild after six weeks.The new material composite PDMS/ZnO-T is well tolerated and the associated foreign body fibrotic reaction quite mild.The new microshunt reduces the IOP for 2 weeks.

Further research will elucidate a tube-like shape to improve and prolong outflow performance and longer follow-up to exclude medium-term adverse effects.